Full member of GSISH

Contact Details

Department of Nuclear Medicine
Klinikum Rechts der Isar
TU München
Room: 01.3a-c
Ismaninger Str. 22
81675 München
Germany

Phone: +49 (0)89.4140.6457

E-Mail: hartl@in.tum.de

Project Details

Project:
Computational modeling of detection physics for 3D intraoperative imaging with navigated nuclear probes

Supervisors:
Prof. Dr. S. I. Ziegler
Prof. Dr. Nassir Navab
Prof. Dr. med. Markus Schwaiger

Start of PhD-work at GSISH:
November 2009

Project Description:
Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.

Publications:

Intraoperative nuclear imaging using navigated gamma-probes for tumor localization
T. Wendler, A. Hartl, J. Traub, S. I. Ziegler, N. Navab
Annual Meeting of Society of Nuclear Medicine, Washington D.C., USA, 2nd-6th June 2007 (SNM 2007), 48: p. 162

Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions
T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. Buck, F. Daghighian, M. Schwaiger, S. I. Ziegler, N. Navab
3rd Russian Bavarian Conference on Biomedical Engineering, Erlangen, Germany, 2nd-3rd July 2007 (RBC Biomed 2007), pp. 96-100

Towards intra-operative 3D nuclear imaging: reconstruction of 3D radioactive distributions using tracked gamma probes
T. Wendler, A. Hartl, T. Lasser, J. Traub, F. Daghighian, S. I. Ziegler, N. Navab
10th International Conference on Medical Image Computing and Computer Assisted Intervention, 29th October - 2nd November 2007, Brisbane, Australia, (MICCAI 2007), pp. 909-917

Towards intra-operative 3D nuclear imaging: developement and evaluation of ad hoc models
A. Hartl, T. Wendler, T. Lasser, J. Traub, S. Ziegler, N. Navab
Annual meeting of Deutsche Gesellschaft für Computer-und Roboter-Assistierte Chirurgie (CURAC 2007), Karlsruhe, Germany

Confidence visualization and robust statistical inference by means of navigation in beta probe surface reconstruction
A. Hartl, T. Wendler, N. Navab
Diploma thesis, Technische Universität München (TUM), München, Germany

3D Intra-operative nuclear imaging for SLNB in neck
T. Wendler, A. Hartl, T. Lasser, J. Traub, S. Ziegler, N. Navab
Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), Houston, USA

Confident radioactivity surface reconstruction for control of resection borders
A. Hartl, T. Wendler, J. Traub, T. Lasser, S. Ziegler, N. Navab
Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), Houston, USA

Tracking-based statistical correction for radio-guided cancer surgery
A. Hartl, T. Wendler, T. Lasser, S. Ziegler, N. Navab
Proceedings of Augmented environments for Medical Imaging and Computer-aided Surgery(AMI-ARCS 2008), New York, USA

A comparison study of two reconstruction methods for gated Cone-Beam CT
A. Hartl, Z. Yaniv
Proceedings of Computer Assisted Radiology and Surgery (CARS 2009), Berlin, Germany

Evaluation of a 4D Cone-Beam CT Reconstruction Approach using a Simulation Framework
A. Hartl, Z. Yaniv
Proceedings of Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, USA

Comparison Study of Detection Models for Nuclear Probes
A. Hartl, N. Navab, S. Ziegler
Proceedings of Annual Meeting of European Association of Nuclear Medicine (EANM 2010), Vienna, Austria

Models of detection physics for nuclear probes in freehand SPECT reconstruction
A. Hartl, S. Ziegler, N. Navab
Proceedings of IEEE Nuclear Science Symposium and Medical Imaging Conference (IEEE/NSS/MIC/RTSD 2010), Knoxville, USA

Evaluation of an ad hoc model of detection physics for navigated beta-probe surface imaging
D. Shakir, A. Hartl, N. Navab, S. Ziegler
Proceedings of SPIE Medical Imaging 2011, Orlando, Florida

Impact of acquisition geometry and physical model on Freehand SPECT reconstructions
A. Hartl, T. Lasser, N. Navab, S. I. Ziegler
Proceedings of IEEE Medical Imaging Conference(IEEE/MIC 2011), Knoxville, Valencia, Spain

Two new ad-hoc models of detection physics and their evaluation for navigated beta probe surface imaging
D. I. Shakir, A. Hartl, F. R. Schneider, J. Pulko, S. I. Ziegler, N. Navab, T. Lasser
Proceedings of SPIE Visualization, Image-Guided Procedures, and Modeling Conference (SPIE 2012), San Diego, California, USA

Freehand SPECT reconstructions using look up tables
A. Hartl, D. I. Shakir, R. Kojchev, N. Navab, S. I. Ziegler, T. Lasser
Proceedings of SPIE Visualization, Image-Guided Procedures, and Modeling Conference (SPIE 2012), San Diego, California, USA

Towards Intra-operative PET for Head and Neck Cancer: Lymph Node Localization Using High-energy Probes
D. I. Shakir, A. Okur, A. Hartl, P. Matthies, M. Essler, S. I. Ziegler, T. Lasser, N. Navab
Proceedings of the 15th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI 2012), Nice, France

Personal Details:

For Curriculum Vitae of Alexander Hartl click here.