Member of GSISH

Contact Details

Department of Nuclear Medicine
Klinikum Rechts der Isar
TU München
Ismaninger Str. 22
81675 München

E-Mail: eugen.kubala(at)tum.de


Diagnostics, Imaging and Biomedical Technologies
GE Global Research Europe
Freisinger Landstr. 50
85784 Garching

Phone: +49(0)89.5528.3716
E-Mail: eugen.kubala(at)ge.com

Project Details

Project:
¹³C Metabolic Magnetic Resonance Imaging with
Hyperpolarized ¹³C-labelled Metabolites

Supervisors:
Prof. Dr. Steffen J. Glaser
Prof. Dr. med. Markus Schwaiger
Dr. Marion I. Menzel

Start of PhD-work at GSISH:
July 2014

Project Description:
Detection of abnormal metabolic fluxes or unusual accumulation of metabolites in tissue could be used to monitor the cancer in humans. Malignant tumor cells are characterized by altered energy metabolism pathways involving substrates such as glucose and glutamine. Imaging of the altered metabolism pathways can not only support the initial diagnosis, but also monitor progress in terms of staging, restaging, treatment response, and identification of recurrence, both at the primary tumor and at distant metastatic sites. Metabolic magnetic resonance imaging with hyperpolarized 13C-labelled substances (13CMMR) allows non–invasive investigation of in vivo metabolism. Using 13CMMR, metabolism of 13C-glutamine, 13C-glutamate, 13C-2-oxoglutarate will be studied in vivo in real time and accumulation and local increase in its metabolism can localize the tumor and find changing in its metabolism.

For curriculum vitae of Eugen Kubala please click here.