Full member of GSISH

Contact Details

University Hospital Schleswig-Holstein
Department of Dermatology, Allergology and Venereology
Schittenhelmstr 7
24105 Kiel
Germany

Phone: +49 (0)431.597.1607
Fax:     +49 (0)431.597.1815

E-Mail: hbaurecht(at)dermatology.uni-kiel.de

Project Details

Project:
Development of a statistical method to identify pleiotropic loci for atopic eczema and psoriasis using GWAS data

Supervisors:
Prof Dr. Stefan Wagenpfeil
PD Dr.med. Stephan Weidinger

Start of PhD-work at GSISH:
February 2010

Project Description:
Atopic eczema and psoriasis are common chronic inflammatory skin diseases which rarely co-exist within the same patient, reflecting mutually exclusive immunological features. Genome-wide association studies have identified eczema- and psoriasis-specific but also co-incident susceptibility loci. These loci may represent overlapping pathophysiological mechanisms and important switch points in pathways determining susceptibility to one or both diseases. Using imputed genome-wide association data from 6 independent case-control cohorts comprising more than 18,000 individuals, we aim to systematically compare and contrast eczema and psoriasis on a genomic level. Analytical approaches based on meta-analysis techniques are developed and applied to the genome-wide datasets.

Publications:

Gerdes S, Laudes M, Neumann K, Baurecht H, Mrowietz U.
"Wnt5a - a potential factor linking psoriasis to metabolic complications."
Exp Dermatol. 2014 Jun;23(6):438-40.

Rodríguez E, Baurecht H, Wahn AF, Kretschmer A, Hotze M, Zeilinger S, Klopp N, Illig T, Schramm K, Prokisch H, Kühnel B, Gieger C, Harder J, Cifuentes L, Novak N, Weidinger S.
"An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis."
J Invest Dermatol. 2014 Jul;134(7):1873-83.

Kretschmer A, Möller G, Lee H, Laumen H, von Toerne C, Schramm K, Prokisch H, Eyerich S, Wahl S, Baurecht H, Franke A, Claussnitzer M, Eyerich K, Teumer A, Milani L, Klopp N, Hauck SM, Illig T, Peters A, Waldenberger M, Adamski J, Reischl E, Weidinger S.
"A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding."
Allergy. 2014 May;69(5):632-42.

Gerdes S, Osadtschy S, Buhles N, Baurecht H, Mrowietz U.
"Cardiovascular biomarkers in patients with psoriasis."
Exp Dermatol. 2014 May;23(5):322-5.

Fischer J, Wu Z, Kantyka T, Sperrhacke M, Dimitrieva O, Koblyakova Y, Ahrens K, Graumann N, Baurecht H, Reiss K, Schröder JM, Proksch E, Meyer-Hoffert U.
"Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury."
J Invest Dermatol. 2014 May;134(5):1305-12.

Hotze M, Baurecht H, Rodríguez E, Chapman-Rothe N, Ollert M, Fölster-Holst R, Adamski J, Illig T, Ring J, Weidinger S.
"Increased efficacy of omalizumab in atopic dermatitis patients with wild-type filaggrin status and higher serum levels of phosphatidylcholines."
Allergy. 2014 Jan;69(1):132-5.

Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG.
"Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects."
J Allergy Clin Immunol. 2013 Nov;132(5):1121-9.

Weidinger S, Willis-Owen SA, Kamatani Y, Baurecht H, Morar N, Liang L, Edser P, Street T, Rodriguez E, O'Regan GM, Beattie P, Fölster-Holst R, Franke A, Novak N, Fahy CM, Winge MC, Kabesch M, Illig T, Heath S, Söderhäll C, Melén E, Pershagen G, Kere J, Bradley M, Lieden A, Nordenskjold M, Harper JI, McLean WH, Brown SJ, Cookson WO, Lathrop GM, Irvine AD, Moffatt MF.
"A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis."
Hum Mol Genet. 2013 Dec 1;22(23):4841-56.

Liedén A, Winge MC, Sääf A, Kockum I, Ekelund E, Rodriguez E, Fölster-Holst R, Franke A, Illig T, Tengvall-Linder M, Baurecht H et al. (2012): Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis. PLoS One;7(11):e49694.

Arnold M, Hartsperger ML, Baurecht H, Rodríguez E et.al. (2012): Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases. BMC Genomics;13:490. doi: 10.1186/1471-2164-13-490.

Rebane A, Zimmermann M, Aab A, Baurecht H, Koreck A  et al. (2012): Mechanisms of IFN-?-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. J Allergy Clin Immunol.;129(5):1297-306.

Stern H, Baurecht H, Luechinger R, Schwaiger M, Hess J, Fratz S.  (2012): Does the amplatzer septal occluder device alter ventricular contraction pattern? A ventricular motion analysis by MR tagging. J Magn Reson Imaging;35(4):949-56.

Paternoster L, Standl M, Chen CM, Ramasamy A, Bønnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP, Albrecht E, Baurecht H et al. (2011): Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet.;44(2):187-92.

Filipiak-Pittroff B, Schnopp C, Berdel D, Naumann A, Sedlmeier S, Onken A, Rodriguez E, Fölster-Holst R, Baurecht H  et al. (2011): Predictive value of food sensitization and filaggrin mutations in children with eczema. J Allergy Clin Immunol.;128(6):1235-1241.e5.

Maintz L, Yu CF, Rodríguez E, Baurecht H et al. (2011): Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Allergy.;66(7):893-902.

Mahachie John JM, Baurecht H, Rodríguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann HE, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S (2009):
"Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on total IgE levels and eczema risk", Allergy 2009.

Rodríguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown SJ, Cordell HJ, Irvine AD, Weidinger S (2009):
"Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease", J Allergy Clin Immunol 123(6):1361-70.

Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodr´guez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A (2009):
"A common variant on chromosome 11q13 is associated with atopic dermatitis", Nat Genet 41(5):596-601.

Weidinger S, Gieger C, Rodríguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Krämer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann HE, Illig T (2008):
"Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus", PLoS Genet 4(8).

Weidinger S, Baurecht H, Wagenpfeil S, Henderson J, Novak N, Sandilands A, Chen H, Rodríguez E, O'Regan GM, Watson R, Liao H, Zhao Y, Barker JN, Allen M, Reynolds N, Meggitt S, Northstone K, Smith GD, Strobl C, Stahl C, Kneib T, Klopp N, Bieber T, Behrendt H, Palmer CN, Wichmann HE, Ring J, Illig T, McLean WH, Irvine AD (2008):
"Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk", J Allergy Clin Immunol 122(3):560-8.

Baurecht H, Irvine AD, Novak N, Illig T, Bühler B, Ring J, Wagenpfeil S, Weidinger S (2007):
Toward a major risk factor for atopic eczema:
"meta-analysis of filaggrin polymorphism data"
J Allergy Clin Immunol 120(6):1406-12.

Naumann A, Söderhall C, Fölster-Holst R, Baurecht H et al. 2011:
"A comprehensive analysis of the COL29A1 gene does not support a role in eczema."
J Allergy Clin Immunol. 2011 Feb 24.

Weidinger S, Baurecht H, Naumann A, Novak N, 2010:
"Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease?"
Curr Opin Allergy Clin Immunol. 2010 Oct. 10(5):408-17.

Jungersted JM, Scheer H, Mempel M, Baurecht H et al. 2010:
"Stratum corneum lipids, skin barrier function and filaggrin mutatuions in patients with atopic eczema"
Allergy, 2010 July, 65(7):911-8.

Mahachie John JM, Baurecht H, Rodriguez E, et al. 2010:
"Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk"
Allergy, 2010 July, 65(7):875-82.

Weidinger S, Willis-Owen SA, Kamatani Y, Baurecht H, Morar N, Liang L, et al. (2013): A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet. 2013 Jul 25. [Epub ahead of print]

Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I, et al. (2013): High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet. 45(7):808-12.

Zeilinger S, Kühnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, et al. (2013): Tobacco smoking leads to extensive genome-wide changes in DNA methylation.
PLoS One 17;8(5):e63812.

Ried JS, Baurecht H, Stückler F, Krumsiek J, Gieger C, Heinrich J, et al. (2013): Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy. 2013 May;68(5):629-36. 

 

Teaching:

SPSS-Courses, Biomathematics computer seminar

Personal Details:

April 2009 - present :
PhD student at Ludwig-Maximilians Universität, Munich and TUM/ GSISH

Oct 2004 - Oct 2006:
Ludwig-Maximilians-Universität, Munich
study in Statistics

Oct 1999 - July 2003:
University of Applied Sciences, Ulm
study in Documentation and Computer Science in Medicine

Oct 1998 - May 1999:
Interlink School of Languages, Cape Town
English courses intermediate and advanced level

Sept 1994 - July 1997:
Wirtschaftsgymnasium, Schwäbisch-Gmünd
Abitur (A-levels)