Associated member of GSISH

Contact Details

Department for Bioinformatics and Computational Biology - I12
Fakultät für Informatik
TU München
Boltzmannstraße 3
85748 Garching
Germany

Phone: +49 (0)89.289.17813
Fax: +49 (0)89.289.19414
E-Mail: vicedo@rostlab.org

Project Details

Project:
Disease Prediction Using Protein Disorders

Supervisor:
Prof. Dr. Burkhard Rost

Start of PhD-work at GSISH:
May 2011

Project Description:
Unstructured proteins (intrinsically disordered proteins and intrinsically disordered regions) lack stable tertiary and/or secondary structure in physiological conditions yer fulfills a biological function. Several disordered proteins were shwon to be associated with human diseases, such as cancer, cardiovascular disease, neurodegenerative diseases, and other. The aim of this project is to predict human diseases based on the disordered proteins.

Publications:
Markus Schmidberger, Esmeralda Vicedo und Ulrich Mansmann: affyPara - a Bioconductor Package for Parallelized Preprocessing Algorithms of Affymetrix Microarray Data, 2009, Libertas, Academica, www.la-press.com/affypara---a-bioconductor-package-for-parallelizedpreprocessing-algor-a1556.

Manuel J. A. Eugster, Jochen Knaus, Christine Porzelius, Markus Schmidberger, and Esmeralda Vicedo: Hands-on tutorial for parallel computing with R, Computational Statistics, 26:219-239, 2011.

Markus Schmidberger, Esmeralda Vicedo, Ulrich Mansmann: Simulation Study for the Agreement between Statistical Methods in Quality Assessment and Control of Microarray Data, Computational Statistics, 2009.

Schlessinger A., Schaefer C., Vicedo E., Schmiedberger M., Punta M., Rost B.: Protein disorder breakthrough invention of evolution?, Current Opinion in Structural Biology, 2011.