Full member of GSISH

Contact Details

Physics Department E17
TU München
James-Franck-Str. 1
85748 Garching
Germany

Phone: +49 (0)89.289.12754
Fax:     +49 (0)89.289.12548

E-Mail: marian.willner@ph.tum.de

Project Details

Project:
Quantitative X-ray phase-contrast tomography for biomedical research at laboratory X-ray sources

Supervisor:
Prof. Dr. Franz Pfeiffer

Start of PhD-work at GSISH:
June 2011

Project Description:
Grating-based X-ray phase-contrast tomography is an emerging modality that is based on a fundamentally different image formation process compared to conventional attenuation-based imaging and might improve diagnostics in the future by providing additional information and enhanced soft-tissue contrast.
In this project, we investigate the potential of the technique for quantitative tissue characterisation and aim to gain insight into its diagnostic capabilities. For this purpose, an experimental phase-contrast imaging system optimised for biomedical research has been developed in our lab. Various studies are performed in strong collaborations with the Radiology Departments of the Klinikum rechts der Isar and the Klinikum Grosshadern. Topics range from oncology to fibrosis and atherosclerotic plaque.

Publications:

Fingerle, A., Willner, M., Herzen, J., Münzel, D., Hahn, D., Rummeny, E., Noel, P. & Pfeiffer, F. (2014),"Simulated Cystic Renal Lesions: Quantitative X-ray Phase-Contrast CT - An in Vitro Phantom Study", Radiology.

Hetterich, H., Willner, M., Fill, S., Herzen, J., Bamberg, F., Hipp, A., Schüller, U., Adam-Neumair, S., Wirth, S., Reiser, M., Pfeiffer, F. & Saam, T. (2014), "Phase-Contrast CT: Qualitative and Quantitative Evaluation of Atherosclerotic Carotid Artery Plaque", Radiology.

Grandl, S., Willner, M., Herzen, J., Sztrokay-Gaul, A., Mayr, D., Auweter, S.D., Hipp, A., Birnbacher, L., Marschner, M., Chabior, M., Reiser, M., Pfeiffer, F., Bamberg, F. & Hellerhoff, K. (2014), "Visualizing Typical Features of Breast Fibroadenomas Using Phase-Contrast CT: An Ex-Vivo Study", PLoS ONE. Vol. 9(5)

Herzen, J., Willner, M.S., Fingerle, A.A., Noël, P.B., Köhler, T., Drecoll, E., Rummeny, E.J. & Pfeiffer, F. (2014), "Imaging Liver Lesions Using Grating-Based Phase-Contrast Computed Tomography with Bi-Lateral Filter Post-Processing", PLoS ONE. Vol. 9(1), pp. e83369.

Willner, M., Herzen, J., Grandl, S., Auweter, S., Mayr, D., Hipp, A., Chabior, M., Sarapata, A., Achterhold, K., Zanette, I., Weitkamp, T., Sztrokay, A., Hellerhoff, K., Reiser, M. & Pfeiffer, F. (2014), "Quantitative breast tissue characterization using grating-based x-ray phase-contrast imaging", Physics in Medicine and Biology. Vol. 59(7), pp. 1557-1571.

Esmaeili, M., Floystad, J.B., Hipp, A., Willner, M., Bech, M., Diaz, A., Royset, A., Andreasen, J.W., Pfeiffer, F. & Breiby, D.W. (2014), "Monitoring moisture distribution in textile materials using grating interferometry and ptychographic X-ray imaging", Textile Research Journal.

Fu, J., Biernath, T., Willner, M., Amberger, M., Meiser, J., Kunka, D., Mohr, J., Herzen, J., Bech, M. & Pfeiffer, F. (2014), "Cone-beam differential phase-contrast laminography with x-ray tube source", EPL (Europhysics Letters). Vol. 106(6)

Mohajerani, P., Hipp, A., Willner, M., Marschner, M., Trajkovic-Arsic, M., Ma, X., Burton, N., Klemm, U., Radrich, K., Ermolayev, V., Tzoumas, S., Siveke, J., Bech, M., Pfeiffer, F. & Ntziachristos, V. (2014), "FMT-PCCT: Hybrid Fluorescence Molecular Tomography - X-ray Phase-Contrast CT Imaging of Mouse Models", IEEE Trans. Med. Imaging.

Fu, J., Willner, M., Chen, L., Tan, R., Achterhold, K., Bech, M., Herzen, J., Kunka, D., Mohr, J. & Pfeiffer, F. (2014), "Helical differential X-ray phase-contrast computed tomography", Physica Medica. Vol. 30(3), pp. 374-379.

Auweter, S.D., Herzen, J., Willner, M., Grandl, S., Scherer, K., Bamberg, F., Reiser, M.F., Pfeiffer, F. & Hellerhoff, K. (2014), "X-ray phase-contrast imaging of the breast-advances towards clinical implementation", British Journal of Radiology. Vol. 87(1034), pp. 20130606.

Tapfer, A., Braren, R., Bech, M., Willner, M., Zanette, I., Weitkamp, T., Trajkovic-Arsic, M., Siveke, J.T., Settles, M., Aichler, M., Walch, A. & Pfeiffer, F. (2013), "X-Ray Phase-Contrast CT of a Pancreatic Ductal Adenocarcinoma Mouse Model", PLoS ONE. Vol. 8(3), pp. e58439.

Saam, T., Herzen, J., Hetterich, H., Fill, S., Willner, M., Stockmar, M., Achterhold, K., Zanette, I., Weitkamp, T., Schüller, U., Auweter, S., Adam-Neumair, S., Nikolaou, K., Reiser, M.F., Pfeiffer, F. & Bamberg, F. (2013), "Translation of Atherosclerotic Plaque Phase-Contrast CT Imaging from Synchrotron Radiation to a Conventional Lab-Based X-Ray Source", PLoS ONE. Vol. 8(9), pp. e73513.

Willner, M., Bech, M., Herzen, J., Zanette, I., Hahn, D., Kenntner, J., Mohr, J., Rack, A., Weitkamp, T. & Pfeiffer, F. (2013), "Quantitative X-ray phase-contrast computed tomography at 82 keV", Optics Express. Vol. 21(4), pp. 4155-4166.

Gaass, T., Potdevin, G., Bech, M., Noël, P.B., Willner, M., Tapfer, A., Pfeiffer, F. & Haase, A. (2013),"Iterative reconstruction for few-view grating-based phase-contrast CT - An in vitro mouse model", Europhysics Letters. Vol. 102(4), pp. 48001.

Pfeiffer, F., Herzen, J., Willner, M., Chabior, M., Auweter, S., Reiser, M. & Bamberg, F. (2013), "Grating-Based X-ray Phase Contrast for Biomedical Imaging Applications", Zeitschrift für Medizinische Physik. Vol. 23(3), pp. 176 - 185.

Grandl, S., Willner, M., Herzen, J., Mayr, D., Auweter, S.D., Hipp, A., Pfeiffer, F., Reiser, M. & Hellerhoff, K. (2013), "Evaluation of phase-contrast CT of breast tissue at conventional X-ray sources - presentation of selected findings", Zeitschrift für Medizinische Physik. Vol. 23(3), pp. 212-221.

Hetterich, H., Fill, S., Herzen, J., Willner, M., Zanette, I., Weitkamp, T., Rack, A., Schüller, U., Sadeghi, M., Brandl, R., Adam-Neumair, S., Reiser, M., Pfeiffer, F., Bamberg, F. & Saam, T. (2013), "Grating-based X-ray phase-contrast tomography of atherosclerotic plaque at high photon energies", Zeitschrift für Medizinische Physik. Vol. 23(3), pp. 194-203.

Noël, P.B., Herzen, , Julia, , Fingerle, A.A., Willner, M., Stockmar, M.K., Hahn, D., Settles, M., Drecoll, E., Zanette, I., Weitkamp, T., Rummeny, E.J. & Pfeiffer, F. (2013), "Evaluation of the potential of phase-contrast computed tomography for improved visualization of cancerous human liver tissue", Zeitschrift für Medizinische Physik. Vol. 23(3), pp. 204-211.

Sztrókay, A., Herzen, J., Auweter, S., Liebhardt, S., Mayr, D., Willner, M., Hahn, D., Zanette, I., Weitkamp, T., Hellerhoff, K., Pfeiffer, F., Reiser, M. & Bamberg, F. (2012), "Assessment of grating-based X-ray phase-contrast CT for differentiation of invasive ductal carcinoma and ductal carcinoma in situ in an experimental ex vivo set-up", European Radiology. Vol. 23(2), pp. 381-387.